تفاصيل الوثيقة
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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Protein remote homology detection is an important task in computational proteomics. Some
computational methods have been proposed, which detect remote homology proteins based
on different features and algorithms. As noted in previous studies, their predictive results are
complementary to each other. Therefore, it is intriguing to explore whether these methods can
be combined into one package so as to further enhance the performance power and application
convenience. In view of this, we introduced a protein representation called profile-based pseudo protein
sequence to extract the evolutionary information from the relevant profiles. Based on the concept
of pseudo proteins, a new predictor, called “dRHP-PseRA”, was developed by combining four stateof-
the-art predictors (PSI-BLAST, HHblits, Hmmer, and Coma) via the rank aggregation approach.
Cross-validation tests on a SCOP benchmark dataset have demonstrated that the new predictor
has remarkably outperformed any of the existing methods for the same purpose on ROC50 scores.
Accordingly, it is anticipated that dRHP-PseRA holds very high potential to become a useful high
throughput tool for detecting remote homology proteins. For the convenience of most experimental
scientists, a web-server for dRHP-PseRA has been established at http://bioinformatics.hitsz.edu.cn/
dRHP-PseRA/. |
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ردمد |
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2045-2322 |
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اسم الدورية |
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Scientific reports |
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المجلد |
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6 |
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العدد |
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1 |
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سنة النشر |
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1437 هـ
2016 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Monday, July 17, 2017 |
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الباحثون
| Junjie Chen | Chen, Junjie | باحث | دكتوراه | |
| Ren Long | Long, Ren | باحث | دكتوراه | |
| Xiao-long Wang | Wang, Xiao-long | باحث | دكتوراه | |
| Bin Liu | Liu, Bin | باحث | دكتوراه | |
| Kuo-Chen Chou | Chou, Kuo-Chen | باحث | دكتوراه | |
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الرجوع إلى صفحة الأبحاث
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